Enbrel works by reducing a certain protein produced by the immune system. The immune system help the body fight disease. In people with autoimmune disorder, the immune system mistake the body's have cells for invaders and attacks them. Enbrel is use to treat the symptoms of rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, and to avoid joint damage caused by these situation. Enbrel is also used to treat plaque psoriasis in adults and polyarticular juvenile idiopathic arthritis in children who are at least 2 years old.