New research has uncovered possible causes of epilepsy associated to signals in the brain that go haywire.

It suggests that when a certain protein is missing in the brains of mice, the animals have epileptic seizures. The protein appears to be important to the brain's aptitude to calm and fine-tune itself.


The researchers, who report their findings in the Sept. 18 issue of Cell, found that neural connections in the brain were emotional in the mice even though connections appeared normal.

When the protein was restored, the brains of the mice began acting usually again.

The specific protein referred to is one encoded by plasticity related gene-1 (PRG-1) and is found only in the brain, according to the researchers. Its calming effect depends on how the protein interacts with lipids that give a signaling function in the brain.

Epilepsy occurs when signals in the brain become disrupted. People with the condition can suffer from a long list of indications, including seizures, strange behavior and emotions, and loss of consciousness.

There's no cure for the disorder, but it can be controlled by medicine and surgery in an predictable 80 percent of cases. In recent years, people with epilepsy have turned to a device that stimulates the body's vagus nerve.