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History Of Brain Tumor

                       Brain tumor

The Brain Tumor Research Center (BTRC) was conceiving a little over 40 years ago at Tulane University School of medication. There, Charles Byron Wilson MD, a resident at Charity Hospital in New Orleans - was upset by the knowledge that neither surgery nor radiation could offer an endurance time of more than about 5 months for patients who have a malignant brain tumor. Deeply involved in and concerned about the dismal outlook for these patients, Wilson thought that future hope might lie in chemotherapy, the make use of of anticancer drugs.

Chemotherapy had originate from medical observations of soldiers showing to sulfur mustard in chemical warfare during World War I. Evidence that the agent lower lymphocyte counts led to the make use of a somewhat less toxic agent, nitrogen mustard, to care for lymphoid cancers (27). By the 1950s, intracarotid vaccination of nitrogen mustard was being used in some centers to treat brain malignancies (21), but by 1961 brain tumor chemotherapy in the United States (US) still concerned little more than an occasional heroic effort to administer a randomly preferred agent to a patient in the final stages of disability (31). In that year, Wilson begins a series of laboratory experiments which, he later said, were based on assumptions that seem amazingly naive in retrospect (31). Trained in neurosurgery and pathology, Wilson published papers on chemotherapy by nonstop arterial infusion in 1962 (28) and on brain tumor tissue culture in 1963 (33).

After faculty scheduled time at Tulane and then Louisiana State University, Wilson recognized the Division of Neurosurgery at the University of Kentucky Medical School in 1963. Between 1963 and 1968, he launches an experimental program to study the activities of brain tumors, the nature and rate of their expansion, and the manner in which they cause death. Among the most promising areas of examination was a series of experiments in which potentially effectual drugs were administered to tumor-bearing rats. Wilson, with Harvard cerebrospinal fluid physiologist Edgar Bering, organized the Kentucky discussion on Brain Tumor Chemotherapy that was held in 1965. Wilson outlined the objective of the discussion before an audience of senior workers in the field - to seek a treat for malignant brain tumors.