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Enamelin is a protein found in tooth enamel. Although less than 5% of enamel consists of protein, enamelins comprise 2% of all enamel protein. They are known as ameloproteases-I, which are enamel proteinases. Although not completely understood, the function of enamelins is believed to be in breaking down amelogenins during tooth development.

Other significant proteins in enamel are amelogenins, ameloblastins, and tuftelins.