There is no cure for congenital Alpha-Mannosidosis. Treatment is less to reducing or controlling the symptoms of this disorder by, for example, taking medication to control seizures, using a hearing aid to assist with hearing loss, and by having continous physical therapy to assist with muscular pain and weakness.
Alpha-mannosidosis is a lysosomal storage disorder caused by deficient activity of the enzyme alpha-D-mannosidase . In humans it is recognized to be caused by an autosomal recessive genetic mutation. In livestock it is caused by chronic poisoning with swainsonine .