Alpers' syndrome, Alpers' Huttenlocher disease, progressive neuronal degeneration of childhood or progressive sclerosing poliodystrophy
There is no cure for Alpers' disease and, currently, no way to slow its sequence. Treatment is symptomatic and supportive. Anticonvulsants may be used to treat the seizures. However, caution should be used when selecting valproate as treatment since it may increase the risk of liver failure. Physical therapy may help to relieve spasticity and maintain or increase muscle tone.
Alpers' disease is a progressive degenerative disease of the central nervous system that occurs frequently in infants and children. It is an autosomal recessive disorder that is sometimes seen in siblings.