Myoadenylate deaminase, also called AMP deaminase, is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia molecule in the procedure. It is a part of the metabolic process that converts sugar, fat, and protein into cellular energy. In order to use energy, a cell converts one of the above fuels into adenosine triphosphate (ATP) via the mitochondria. Cellular processes, especially muscles, then convert the ATP into adenosine diphosphate (ADP), fr
Symptomatic relief from the result of MADD may sometimes be achieved by administering ribose orally at a dose of about 10 grams per 100 pounds (0.2 g/kg) of body weight per day. And exercise modulation as appropriate.
Myoadenylate deaminase deficiency (MADD) is a recessive genetic metabolic disorder that affects about 1-2% of populations of European descent (making it a not particularly "rare" rare disease). It appears to be significantly rarer in Asian populations.